Xenogeneic β2-Microglobulin Substitution Alters NK Cell Function
نویسندگان
چکیده
منابع مشابه
Amniotic Fluid β2- Microglobulin Measurements
OBJECTIVE: To determine β2-microglobulin levels in amniotic fluid during the course of second trimester. STUDY DESIGN: One hundred patient’s amniotic fluid β2-microglobulin levels had been evaluated retrospectively (March-October 2009). The most common amniocentesis indication was advanced maternal age (33.3%). Others were; high risk result for triple test (18.5%), high risk result for double t...
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متن کاملXenogeneic beta 2-microglobulin substitution affects functional binding of MHC class I molecules by CD8+ T cells.
NK cells and CD8+ T cells bind MHC-I molecules using distinct topological interactions. Specifically, murine NK inhibitory receptors bind MHC-I molecules at both the MHC-I H chain regions and beta2-microglobulin (beta2m) while TCR engages MHC-I molecules at a region defined solely by the class I H chain and bound peptide. As such, alterations in beta2m are not predicted to influence functional ...
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To impair MHC class I (class I) function in vivo in the amphibian Xenopus, we developed an effective reverse genetic loss of function approach by combining I-SceI meganuclease-mediated transgenesis with RNAi technology. We generated transgenic outbred X. laevis and isogenetic laevis/gilli cloned lines with stably silenced expression of β2-microglobulin (b2m) critical for class I function. Trans...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2007
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.179.3.1466